Design and Assembly of a Large-aperture Nb3Sn Cos-theta Dipole Coil with Stress Management in Dipole Mirror Configuration

The stress-management cos-theta (SMCT) coil is a new concept which has been proposed and is being developed at Fermilab in the framework of US Magnet Development Program (US-MDP) for high-field and/or large-aperture accelerator magnets based on low-temperature and high-temperature superconductors. The SMCT structure is used to reduce large coil deformations under the Lorentz forces and, thus, the excessively large strains and stresses in the coil. A large-aperture Nb3Sn SMCT dipole coil has been developed and fabricated at Fermilab to demonstrate and test the SMCT concept including coil design, fabrication technology and performance. The first SMCT coil has been assembled with 60-mm aperture Nb3Sn coil inside a dipole mirror configuration and will be tested separately and in series with the insert coil. This paper summarizes the large-aperture SMCT coil design and parameters and reports the coil fabrication steps and its assembly in dipole mirror configuration

Self-Field Effects in Magneto-Thermal Instabilities for Nb-Sn Strands

Recent advancements in the critical current density (Jc) of Nb$_{3}$Sn conductors, coupled with a large effective filament size, have drawn attention to the problem of magnetothermal instabilities. At low magnetic fields, the quench current of such high Jc Nb$_{3}$Sn strands is significantly lower than their critical current because of the above-mentioned instabilities. An adiabatic model to calculate the minimum current at which a strand can quench due to magneto-thermal instabilities is developed. The model is based on an 'integral' approach already used elsewhere [1]. The main difference with respect to the previous model is the addition of the self-field effect that allows to describe premature quenches of non-magnetized Nb$_{3}$Sn strands and to better calculate the quench current of strongly magnetized strands. The model is in good agreement with experimental results at 4.2 K obtained at Fermilab using virgin Modified Jelly Roll (MJR) strands with a low Residual Resistivity Ratio (RRR) of the stabilizing copper. The prediction of the model at 1.9 K and the results of the tests carried out at CERN, at 4.2 K and 1.9 K, on a 0.8 mm Rod Re-Stack Process (RRP) strand with a low RRR value are discussed. At 1.9 K the test revealed an unexpected strand performance at low fields that might be a sign of a new stability regime

Nb3AlNb_{3}Al prototype conductor for the transmission line magnet

The Very Large Hadron Collider (VLHC), under consideration for construction at Fermilab in the next 1-2 decades, is a 100 TeV cm pp collider. A major cost driver is the magnet. R&D is underway on several possible magnet designs. A low-field (2T) superferric magnet, sometimes called a transmission line magnet, may be the most cost- effective route to the VLHC. Although NbTi is now the cheapest superconductor measured in cost/kA-meter, Nb/sub 3/Al has the potential advantage that it remains superconducting at higher temperature. It may be particularly suited to the single "turn" and long straight lengths of the transmission line design. The combination of the simple magnet design and the higher strain tolerance than e.g. Nb/sub 3/Sn allows a simple process of cable fabrication, reaction, and magnet assembly. This higher strain tolerance is an advantage for splicing in the field. Sumitomo Electric Industries is producing an Nb/sub 3/Al conductor for the Fermilab low-field magnet program. (9 refs)

Jagged2 controls the generation of motor neuron and oligodendrocyte progenitors in the ventral spinal cord

In the developing spinal cord, motor neurons (MNs) and oligodendrocytes arise sequentially from a common pool of progenitors. However, the genetic network responsible for this neurogenesis to gliogenesis switch is largely unknown. A transcriptome analysis identified the Notch ligand Jagged2 (JAG2) as a Sonic hedgehog-regulated factor transiently expressed in MN progenitors (pMNs). In vivo loss- and gain-of-function experiments show that JAG2 schedules the differentiation of the pMN progenitors. At early developmental stages, Olig2 expressing pMN progenitors that enter the differentiation pathway exclusively generate MNs. At these times, the activation of the Notch pathway by JAG2 maintains selected pMN progenitors in an undifferentiated state by two mechanisms; first it inhibits MN generation by reducing Olig2 proteins levels, and second it directly inhibits the premature generation of oligodendrocyte progenitors (OLPs) by maintaining high levels of Hes5. Later, extinction of JAG2 from the pMN results in the loss of Hes5 expression, heralding the gliogenic phase of pMN progenitors. Strikingly, downregulation of JAG2 in pMN progenitors is sufficient to promote the precocious generation of OLPs. Together these data provide evidence that JAG2 is a key regulator of the timely and ordered generation of two of the defining cell types in the spinal cord, MNs and OLPs

Development and Test of a Single-Aperture 11 T Nb3Sn Demonstrator Dipole for LHC Upgrades

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Quench Protection Study of a Single-Aperture 11 T Nb3Sn Demonstrator Dipole for LHC Upgrades

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Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration.

Gas1 and Boc/Cdon act as co-receptors in the vertebrate Hedgehog signalling pathway, but the nature of their interaction with the primary Ptch1/2 receptors remains unclear. Here we demonstrate, using primordial germ cell migration in mouse as a developmental model, that specific hetero-complexes of Ptch2/Gas1 and Ptch1/Boc mediate the process of Smo de-repression with different kinetics, through distinct modes of Hedgehog ligand reception. Moreover, Ptch2-mediated Hedgehog signalling induces the phosphorylation of Creb and Src proteins in parallel to Gli induction, identifying a previously unknown Ptch2-specific signal pathway. We propose that although Ptch1 and Ptch2 functionally overlap in the sequestration of Smo, the spatiotemporal expression of Boc and Gas1 may determine the outcome of Hedgehog signalling through compartmentalisation and modulation of Smo-downstream signalling. Our study identifies the existence of a divergent Hedgehog signal pathway mediated by Ptch2 and provides a mechanism for differential interpretation of Hedgehog signalling in the germ cell niche

Study of high field superconducting solenoids for muon beam cooling

The final beam cooling stages of a possible Muon Collider may require DC solenoid magnets with magnetic fields of 40-50 T in an aperture of 40-50 mm. In this paper we study possible solutions towards creating DC fields of that order using available superconductors. Several magnetic and mechanical designs, optimized for the maximum performance are presented and compared in terms of cost and size